Abstract: By adopting a manufacturing process combining forging, rolling and extruding on a Pilger pipe mill, a Φ610 mm TC4 big diameter titanium alloy hot rolled seamless tube is developed.According to the tests, all technical parameters of the product can meet the requirements of ASME SB 861-2013 for Gr5.The comprehensive performances of the product are good, and the longitudinal performances and the transversal performances are uniform.The successful development of the product remarkably expands the upper limit of OD of titanium alloy hot rolled seamless tube from 219 mm to 610 mm.It also significantly lowers the manufacturing cost and period, since the major deforming procedures only include rotary piercing and Pilger rolling.