Abstract: Described here in the essay are the production of the PSL2 X65QO/X65QS seamless steel pipe for service of submarine anti-corrosion pipeline, involving such aspects as product technical difficulties, design of the steel type chemical composition, manufacturing process, and heat treatment process etc.And statistically analyzed are the mechanical properties and the end inner roundness of the said pipe.Moreover HIC test, SSC test and test for welding process evaluation are also conducted to the pipe, as per applicable specifications.The test results demonstrate that the PSL2 X65QO/X65QS seamless steel pipe for service of submarine anti-corrosion pipeline is in possesion of such excellent mechanical properties as slightly-fluctuated strength, high uniform elongation, low impact toughness and low hardness, good weldability and remarkable HIC and SSC resistance, having been satisfactory to relevant customer requirements.